If you've just got it you should know theres an anti-vibration set up in the lower drive cages.
You can put any 5 1/4 thing in place of the floppy bay like a controller.
Usually the side and rear extract. One from the cpu zone and the other the gpu. Theres no prob with 4 exhaust but only one inlet. The case is both heat sink and inlet for air flow. Thats why the design has holes.