I have been running this board since the day it was officially released. With the exception of changing hardware it has been on 24/7. I have had OCZ, Corsair and Crucial memory in it at settings of 900/3-3-3 to 1300+/5-5-5. I doubt there is anyone posting in this thread that has within reason pushed the board or components harder then I have. I've yet to have any ram deteriorate from being run on this board.