In operation, double DDCs likely won't subject the system to more than about 11psi, triples maybe 17psi, RD-30 maybe 14psi.
In practice I think it's been common enough to see dual DDCs that they are relatively tested to a comfort level, but triples are pretty new and not tested a whole bunch.
We don't know about the pressure rating on most parts so it's anybody's guess on that? Perhaps the manufacturers can start posting pressure specs??
Regardless, I suspect the weak point is the fitting/barb pull out on the tubing, especially anything that's been removed/put back together, and particularly with some compression fittings that have small barbs. A 1/2" tube at 17psi is receiving about a 3.5 lb normal force trying to pull the tubing off the barb. I'd be a little uncomfortable with that sort of pressure unless I had a standard barb and worm drive clamp.
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