Well you can run tighter tRD with X48 than P45 no doubt, but loosening tRD while working on CPU speed is never a bad idea.
On P5Qs w/ 8 GB, you pretty much have to run PL10 if you use 1:1 (for anything but low FSB).
5:6 or higher allows me PL8, but then i have to run lower CPU speed as the RAM only goes so high.
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