I already have applied most of the OCZ tweaks. The drive is fine for normal usage afterwards, but it is still not all that hard to choke it with random writes.

I am finding that disabling Superfetch is not worth it on a desktop (especially if you have other rmechanical drives still). Superfetch causes stuttering when you initially start up and it is populating RAM. Once that is complete, it seems to alleviate potential stuttering somewhat as it is probably freeing up the SSD to service more writes.

Disabling Superfetch does stop the initial stuttering on boot up, but I seem to get a lot more random stuttering with it off, where I get almost no stuttering during normal use with it on. It would make more sense to disable it on a laptop as you will likely be rebooting it more often.

Firefox was also killing performance until I moved my profile off the SSD.