Flow seems very good, so without having the means to measure it, I'm guessing it's not impacted much, if at all. During the bleed of the loop, the return line from the NB block was churning the water quite a bit inside the res (still is, just isn't as visible without air in the loop)...which leads me to believe the restrictions and the pump orientation aren't causing flow problems.

On a side note, the system was fully bled within ~6 hours of run time. I like having the res instead of a T-line.