I am a fan of itx with riser. But the problems for me in this case are dust and power. Because it isn't high power, it won't have much of a dust problem. You can use modest but fast hardware that is also quiet under load if you pick carefully. But if I want a 4.2ghz ivy bridge and a gtx 670, I'm not sure that is possible in a case pushed so small.

What is the highest power picopsu? 160w? Did you research a custom psu board with more power? There have been 200w+ ones out there.

So this case is definitely good. But I have a hard time with a premium cost case that can't take premium cost hardware. You can get by with stock ivy bridge and no hard drive space and no dust filters (as long as you can get in easily with canned air), but the idea of downgrading to a lower res monitor, games and running a gtx 660 or 7770 doesn't get me so hot and bothered.