I'm running SLI with 2x 480's in slot #1 and #3, this blocks off my PCI slot for my soundcard, Do I have to skip this soundcard and use the built in one?
The board is designed for a PCI-E soundcard with either 2 triple slot, or 3 dual slot GFX cards unfortunately.
You could maybe sell your current soundcard and get a nice PCI-E one.
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