Depending on what your doing turning off page file isn't a good idea.
I have 8gb's of ram and when I using Photoshop it ran out of ram and the system crashed and was unrecoverable so I lost a load of work. Usually the system comes up with a warning asking you to close non-essential applications but that's hardly ideal if you are working on a load of files. If you just gaming or not using apps that eats any resources you system has it should be ok though.

I compromised by having the minimum page file size at 16mb when your PC starts so windows won't write to a page unless your system is completely out of ram, and in that situation you will be glad you didn't disable it.