Try this and then go for lower volts/timings if it's stable:

Code:
****** Gigabyte EP45 UD3P Bios F7 ******

E8500 510 X 8 4080MHz 

Robust Graphics Booster.........................[ Auto     ] 
CPU Clock Ratio.................................[ 8        ] 
Fine CPU Clock Ratio............................[ 0        ] 
CPU Frequency 4.0GHz...........................[ 510 x 8  ]

******Clock Chip Control******

CPU Host Clock Control..........................[ Enabled  ] 
CPU Host Frequency (Mhz)........................[ 510      ] 
PCI Express Frequency (Mhz).....................[ 100      ] 
C.I.A 2 [Disabled] 

******Advanced Clock Control******

CPU Clock Drive.................................[ 800mv   ] 
PCI Express Clock Drive.........................[ 900mv   ] 
CPU Clock Skew..................................[ 0ps] 
MCH Clock Skew..................................[ 0ps     ] 

******DRAM Performance Control******

Performance Enhance.............................[ Standard ] 
Extreme Memory Profile (XMP)....................[ Disabled ] 
(G) MCH Frequency Latch.........................[ 400MHz   ] 
System Memory Multipler.........................[ 2.00D    ] 
Memory Frequency 1066...........................[ 1000      ] 
DRAM Timing Selectable..........................[ Manual   ] 

CAS Latency Time................................[ 5        ] 
tRCD............................................[ 5        ] 
tRP.............................................[ 5        ] 
tRAS............................................[ 18       ] 

******Advanced Timing Control******

tRRD............................................[ 4        ] [Auto] 
tWTR............................................[ 4        ] [Auto] 
tWR.............................................[ 8        ] [Auto] 
tRFC............................................[ 54       ] [Auto] 
tRTP............................................[ 4        ] [Auto] 
Command Rate (cmd)..............................[ 2T       ] 

******Channel A Timing Settings******     

Static tRead Value        [ 11 ] ................[ Auto    ] Try 12 also
tRD Phase0 Adjustment     [ 1 ] ................[ Auto     ]
tRD Phase1 Adjustment     [ 0 ] ................[ Auto     ]
tRD Phase2 Adjustment     [ 0 ] ................[ Auto     ]
tRD Phase3 Adjustment     [ 0 ] ................[ Auto     ] 

tRD 2rd (Differnt Rank)   [ 8 ] ................[ Auto     ]
tWR 2wr (Differnt Rank)   [ 8 ] ................[ Auto     ] 
tWR 2rd (Differnt Rank)   [ 7 ] ................[ Auto     ] 
tRD 2wr (Same/Difft Rank) [ 9 ] ................[ Auto     ] 

Dimm 1 Clock Skew Control.......................[ Auto     ] 
Dimm 2 Clock Skew Control.......................[ Auto     ] 
DDR Write Training..............................[ Auto     ] 

******Channel A Driving Settings****** 

Drive Strength Profile..........................[ Auto     ] 
Data Driving Pull Up Level......................[ Auto     ] 
cmd Driving Pull Up Level.......................[ Auto     ] 
ctrl Driving Pull Up Level......................[ Auto     ]
clk Driving Pull Up Level.......................[ Auto     ]

Data Driving Pull Down Level....................[ Auto     ] 
cmd Driving Pull Down Level.....................[ Auto     ] 
ctrl Driving Pull Down Level....................[ Auto     ] 
clk Driving Pull Down Level.....................[ Auto     ]

******Channel B Timing Settings******     

Static tRead Value        [ 11 ] ................[ Auto    ] Try 12 also
tRD Phase0 Adjustment     [ 0 ] ................[ Auto     ]
tRD Phase1 Adjustment     [ 0 ] ................[ Auto     ]
tRD Phase2 Adjustment     [ 0 ] ................[ Auto     ]
tRD Phase3 Adjustment     [ 0 ] ................[ Auto     ] 

tRD 2rd (Differnt Rank)   [ 8 ] ................[ Auto     ]
tWR 2wr (Differnt Rank)   [ 8 ] ................[ Auto     ] 
tWR 2rd (Differnt Rank)   [ 7 ] ................[ Auto     ] 
tRD 2wr (Same/Difft Rank) [ 9 ] ................[ Auto     ] 

Dimm 1 Clock Skew Control.......................[ Auto     ] 
Dimm 2 Clock Skew Control.......................[ Auto     ] 
DDR Write Training..............................[ Auto     ] 

******Channel B Driving Settings****** 

Drive Strength Profile..........................[ Auto     ] 
Data Driving Pull Up Level......................[ Auto     ] 
cmd Driving Pull Up Level.......................[ Auto     ] 
ctrl Driving Pull Up Level......................[ Auto     ]
clk Driving Pull Up Level.......................[ Auto     ]

Data Driving Pull Down Level....................[ Auto     ] 
cmd Driving Pull Down Level.....................[ Auto     ] 
ctrl Driving Pull Down Level....................[ Auto     ] 
clk Driving Pull Down Level.....................[ Auto     ]

******Motherboard Voltage Control******

Load-Line Calibration...........................[ Disabled ] 
CPU Vcore         [ 1.25000 ]...................[ 1.41250 ] 
CPU Termination   [ 1.20    ]...................[ 1.30  ]
CPU PLL           [ 1.50    ]...................[ 1.5000  ]  
CPU Reference     [ 0.760   ]...................[0.823    ] 

MCH Core          [1.100    ]...................[ 1.400   ]  
MCH Reference     [0.760    ]...................[ 0.783     ] Try 0.783-0.823 + step or two up
MCH/DRAM Refernce [0.900    ]...................[ 1.100     ] 
ICH I/O           [1.500    ]...................[ 1.500     ] 
ICH Core          [1.100    ]...................[ 1.100   ] 

DRAM Voltage      [1.800    ]...................[ 2.200    ] 
DRAM Termination  [0.900    ]...................[1.100   ] 
Channel A Ref     [0.900    ]...................[ 1.100      ] 
Channel B Ref     [0.900    ]...................[ 1.100      ]