I use 8.04 Kubuntu 64bit I like the KDE gui being a previous windows user it was closer to what I had been used to. As for a guide the Folding Forum over on the FAH site is pretty good there is also some useful info on the Ubuntu Forum as well. For the GPU client using wine there is a very good guide here on this forum and there is also a great thread over on the FAH GPU forum about using the gpu client in Linux using wine. Honestly Linux is not that hard once you really give it a shot I would recommend setting up a dual boot initially with the Windows of your choice leaving a 100 gig or so hdd space free then installing Linux as a dual boot then you can access windows when you wish for gaming and such and still boot into Linux to get more comfortable with it. That is what I did initially I spent most of the time booted into WinXp but over time I started to spend less and less time in windows honestly I have not booted into WinXP on my computer at home in a couple of months now. I have been able to find free Linux alternatives to pretty much all the windows applications I was using and as a side benefit everything runs faster and is more stable I have not seen a BSOD in almost a year now since I pretty much switched from windows.