1 PA is MORE than enough for a e8600 + 4850, i'm sure that even a mcr220 internally with some medium speed yates (1350) should be enough to cool down your rad

your nb won't be a problem in this case as the 2 120mm fans have perfect air distribution and give enough airflow to all components

v350 on million dollar pc

move the pump to the lower 5.25" drive bay using the stock ddc-2 top with t-line (requires some modding), you should be able to fit 1 HDD and the pump in the lower one + the 4th hdd in the upper 5.25" bay and go for an external ODD drive

other solution for the HDDS: if you don't want to raid the drives the easiest solution is to get an external esata enclosure which can hold 2 drives

this way you have a more compact case (with a little bit higher temps) but with moderate overclocks (around 4.0-4.4 ghz there shouldn't be a problem (my TRUE with a medium yate can old the temps below 65°C on my cpu with 28°C room temp)