The only way I can get it to work is to remove the -gpu 0 and -gpu 1---but my points/ folding rate are half of what they should be. However, that is in the shortcut properties. I will try it in the client parameters and report back.

Also, I have no-cpu-lock checked, but both instances were set to core 3. I changed one to core 2--but it doesn't seem to matter. They are running properly--just at half the rate. Task manager shows 3% cpu usage for each instance--and that's about right from what I have seen.

Sparky, if you have not looked through this yet--please do.....Its for GPU and Multi-GPU setup--vista and XP:

http://www.hardforum.com/showthread.php?t=1330889