I don't see why it would. Orthos runs Prime95. It also only spawns up to two threads, so you'd need multiple copies for a quad.
Use the 25.x series of Prime95 builds:
ftp://mersenne.org/gimps/p95v255a.zip
If you really want to stress your CPU, set it up to use small FFTs and match the memory usage to a core's share of the on-chip cache of whatever processor you're testing.
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