In case it might help someone - bios settings for rock stable 4GHz (8hrs Orthos Smal FFTs) on my E8500, 4x1GB Crucial Ballistix PC8000, bios 11/1, watercooled CPU/NB/SB/PWM/GPU.
Code:
CPU Feature
Thermal Management Control >>> Disabled 
PPM (EIST) Mode >>> Disabled 
Limit CPUID MaxVal >>> Disabled 
CIE Function >>> Disabled 
Execute Disable Bit >>> Enabled
Virtualization Technology >>> Enabled
Core Multi-Processing >>> Enabled 

DRAM Timing
Enhance Data transmitting >>> Fast 
Enhance Addressing >>> Fast 
T2 Dispatch >>> Disabled 
Clock Setting Fine Delay 
   Ch1 Clock Crossing Settting >>> More Aggresive
   Ch2 Clock Crossing Settting >>> More Aggresive
   Ch1Ch2 CommonClock Setting >>> More Aggresive
   other subtimings >>> auto/current
CAS Latency Time (tCL) >>> 5
RAS# to CAS# Delay (tRCD) >>> 5 
RAS# Precharge (tRP) >>> 4  
Precharge Delay (tRAS) >>> 9 
All Precharge to Act >>> 4
REF to ACT Delay (tRFC) >>> 30  
Performance Level >>. Auto
Read delay phase adjust >>> auto (all)
MCH ODT Latency >>> 1
Write to PRE Delay (tWR) >>> 12  
Rank Write to Read (tWTR) >>> 10  
ACT to ACT Delay (tRRD) >>> 3  
Read to Write Delay (tRDWR) >>> 8  
Ranks Write to Write (tWRWR) Auto
Ranks Read to Read (tRDRD) Auto
Ranks Write to Read (tWRRD) Auto
Read CAS# Precharge (tRTP) >>> 3
ALL PRE to Refresh >>> 4

Voltage Settings
CPU VID Control >>> 1,35000 
CPU VID Special Add >>> Auto 
DRAM Voltage Control >>> 2,19 
SB Core/CPU PLL Voltage >>> 1,640 
NB Core Voltage >>> 1,430
CPU VTT Voltage >>> 1,160
VCore Droop Control >>> Disabled 
Clockgen Voltage Control >>> 3,45
GTL+ Buffers Strength >>> Strong 
Host Slew Rate >>> Weak 
GTL REF Voltage Control >>> Enable
   CPU GTL1/3 REF Volt >>> 62
   CPU GTL 0/2 REF Volt >>> 60
   North Bridge GTL REF Volt >>> 70
DRAM Timing 
PCIE Slot Config 1X 1X 
CPU Spread Spectrum Disabled 
PCIE Spread Spectrum Disabled 
SATA Spread Spectrum Disabled 

Exist Setup Shutdown >>> Mode 2 
Shutdown after AC loss >>> Disabled
CLOCK VC0 divider >>> Auto
CPU Clock Ratio >>> 8x 
CPU N/2 Ratio >>> Disabled
Target CPU Clock >>> 4000 MHz
CPU Clock >>> 500 MHz
Boot Up Clock >>> Auto 
DRAM Speed 333MHz/667 
Target DRAM Speed DDR2 >>> 10001  
PCIE Clock >>> 100MHz 
PCIE Slot Config >>> 1x 1x
See 8hrs Orthos Small FFTs session below


One more word about memory performance... After "transforming" Windows XP from LanParty P35 to X38 setup without reinstall, memory performance looks like this... I think that system reinstall might help (a lot)... Although I do not care for every MB/s - try to focus on Voltages optimisation


Hope it helps someone