If your machine is otherwise stable, I wouldn't worry about Orthos. My "ernie" machine couldn't pass a 30 minute Orthos but hasn't locked up or otherwise had a problem in months and I push my machines pretty hard.
Having said that, your vcore is pretty low so you have plenty of room to increase. If the Orthos fail bugs you, try increasing vcore in small steps (watching your temps of course) and see how much voltage you need to be stable.
Knowing your memory settings and what the Orthos error message was will help also.
With only 1 drive (and a CD/DVD I assume) a 420 should be OK.

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