How would I look into avoiding SATA HD issues when overclocking on a 590 reference board?

This Brisbane 1.9ghz is a sweet one, it has no problem with orthos at 2.9ghz on stock voltage, but even with a lower HTT multi (3x) it still might currupt something on restart.

The confusing thing is that it doesn't seem to mind the DDR2 400 multiplier, but if I got to the 533 that's when I get a lot more instability, I don't see why my RAM would affect the SATA drive though.