I had a bad molex to sata that I put in a friend's computer. Caused no end of problems, but the only reason I used it was because it was a really unconventional case style and made cable routing much easier. It would just cut out power to the drive, and this screwed up the Window's install. So I could see that happening. I don't see too many people using a molex to sata with a 480GB Vertex 3 though... probably not likely.