One problem I have with this board - no PCI 1x slot in betwen the middle two Orange slots
This is a very important slot position for people running two graphics cards plus a soundcard, it gives you 3 slot spacing for two GFX cards in 16x slots 1 + 3 (the third slot massively improves heat dissipation and reduces GPU temps), and a slot for a soundcard in the middle.
For a board this expensive, the slots should at least be done right, as the layout on the R3E is.
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