I only have one basis for equating the 480 for CUDA ... on Collatz sftp (the major dude who contributed a 470 and a 480 to GPUGrid) said his 295 would crunch a WU in 18minutes. My 480 is cranking them out in 7 minutes. That is not to say GPUGrid will do better or worse in optimizations but as the only piece of evidence I can point to it looks pretty good to me. Lastest post from GPUGrid regarding fermi is they expect to have a linux version ready tomorrowthey are now focused on optimizations and they may have a Windows version ready also. Hold on to your hats, I'm gonna put up some serious numbers (well for me anyway )

The guys at GPUGrid really do move along quite quickly. If you follow all the different tech they try out and the papers they publish, top it off with the public project ... they are Xtreme