First, welcome to xtremesystems! Second, you should do a project log as this will be awesome. You will love the MM case, I personally prefer going horizontal on the MB as it is easier work on IMHO. I have done a triple loop before, GPU's in one, NB/SB and mosfets in another and the CPU on it's own. The MCP355 pump will be enough for each loop and if you are going this big I would do three independent loops, if you can why not, right? Anyway, I would direct the air flow over the rads into the case. That case is big enough to have exhaust ports to let it equalize. Quick disconnects are nice, been using them for about a year and every time I take them out I end up putting them back in. I would consider doing a pump/res combo to make it easier to set up, but I like the T-virus, looks very cool. If you haven't already gotten the 960, I would skip it and either get a 920 or go for the gold and get the 980x, either way you will not be disappointed. I have had the 975, the 960 and the 920 and the 920 will perform as good if not better than the other two unless you are doing extreme cooling. As far as doing a chiller, sure you could, but then you have to either be able to control the water temp or insulate, done that one two and it was fun, but I went back to just water. I would do a phase unit before I would do a water chiller, more compact and and better temps. Like it has already been mentioned, having the front off while installing your gear makes things easier. If you plan on doing SLI with two or three GTX480's, then rethink the PSU, maybe something slightly larger. Better to do it now and not need it then not have it and need it. Install a fitting with three ports towards the bottom of each loop so you can install a drain. I use a QD there so I can just plug in and drain, easy, peasy. The last thing to remember is to have fun with it. Don't be afraid to change things once you get it setup, this is a hobby and should be fun.