The original fans in this case is VERY silent, i couldnt hear it while i had that case. The screws on theese fans are tightened down pretty well, so in terms of vibration, i suppose i could say no. Not alot of that in this case.
And to your second question, yes that would be an issue, since those drives rely on the HDD to hit those "screws" on both sides. Aka.. being a 3,5" disc.

But anyway.. i dont see any problem in mounting it in one of the dvd drive bays? Just screw it into place on the opposite side of those hot swap thingys. Hope you understood what i ment here :P