Question is, what case and video card would you pair up with this? Seems kinda pointless to have all this capability without being able to fit it in an itx case.

It would be good for an HTPC, but if that's all you are using it for even an atom+ion board will do the trick. Or, you need a little more power for it to be a workstation i5 is still probably overkill. So, besides that, you have a SSF gaming computer. But, I think the only higher end graphics cards you would fit in an itx case would be like the 5750, which really doesn't need an i5 to back it up. That leaves you with a system with a lot of potential set back by physical limitations.

That doesn't mean I'm condemning the board, but I'd like to see what hardware people would pair with this.