No issues at all at stock on first boot up, or with rated speed/timings/voltages, or with the trial OC. I was actually a bit surprised, as with my last several rigs I've run 8 gigs with all four slots and I always had some issue at first boot until I set voltages in the BIOS. Even my last board, which was rock solid with everything I threw at it (a P5Q Deluxe,) wouldn't boot an OS until I manually set stock speed, timings, and voltages with the 8 gigs of 800mhz / CAS4 RAM I had.