@mtl777: The article is based on the K8 architecture, there have been quite some improvements in K10. If you had cared to check PhenomMsrTweaker's webpage (link's in the first post), you would have come across my statement that the performance of single-threaded applications may be vastly improved (by more than 20% on my X4 9950) when using its custom C&Q instead of the standard one.
Regarding RMClock, I haven't heard of it being used for K10 CPUs, so there's probably no support for the newer architecture. The article's author also mentions that it does not use a service, so you can only use it if someone's logged into the PC (i.e. not very useful for server machines) - PhenomMsrTweaker features such a service, which also gets rid of the annoying UAC prompt right after booting when an autostart program requires elevated privileges.

@Mechromancer: I don't know what you mean by "Particle", but anyway: Istanbul should be supported, as well as CPUs with even more cores (I think I used a limit of 64 cores) - it's just not implemented in the GUI, but usable in the service. You need to dive into the registry, surf to HKLM\Software\PhenomMsrTweaker and adjust the P0 and P1 strings accordingly - just add the missing multipliers, e.g. change something like "10|10|10|10|1.3|1.2" to "10|10|10|10|10|10|1.3|1.2" (the first values are the core multipliers, the second last one is the core VID and the last one the NB VID). Restart the service or reboot, and the settings should have been applied.