Ironically enough, i never had a SINGLE issue with ANY Catalyst driver. Radeon 9600 Pro, Radeon x1950 Pro and now Radeon HD4850.
Same goes for NVIDIA cards. Just stay away from multi-GPU solutions. They are fast when they somehow manage to work, but compatibility equals dog on a sidewalk most of the time. I prefer slightly lower framerate and a problem free experience.
So far it was working perfectly.