Case would be on its front actually as you want the reservoir to be the lowest point in the loop so gravity can do it's thing.
If your referring to bleeding off the air or, "burping the baby =)" then yes you would tilt the case onto it's back so that the reservoir is the highest point in the loop and would trap and hold any air in the loop, and yes you can run your pump during this process because the reservoir is still sitting on top of the pumps main inlet...unless your like a liter short in which case you need to shut off your PC till your sober
Hope that's a little more clear =)





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