I would but I am using my M2F which doesn't have that setting. I was doing some testing with the P5Q-D last night (which does have that setting) but it's back in the box now.
With older bioses I found it didnt really have any effect on anything, but it may have been poorly implemented in earlier versions. It really seems to affect quads more than duals, but more in the sense of simply providing stability, as it was causing quad users some major hassles if set incorrectly before BIOS 1406 IIRC (I only tried it with BIOS 1201).
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