As I said in the first post, most people start with 0.667x Vtt for 65nm and 0.635x Vtt for 45nm, however intel state use 0.667x for both processes, so I'd simply advise anyone to start with 0.667x, and work from there. Some have found lowering it to work best, others need to raise it.
As Mikey said, try to aim for around 0.80v, so that means as you raise/lower Vtt, you must adjust the GTL Ref multiplier to maintain the desired target voltage. If you have a BIOS that has the fixed multiplier and the Y value, use the formula and add or subtract the appropriate Y value to give the desired output voltage.
EDIT - I also use the Orthos calculation error frequency to tune GTL Refs, it seems to be the best way of doing it.
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