That's a very valid question.

The 4870 is gonna be in the furthermost PCI-E slot, so on the far right of that picture. I'd hope that the tubing could be pushed down to clear the frame. Note that this would only be an issue when i want to slide the mobo tray in or out of the case. In both these scenarios the loop would be dry/drained, thus reducing the risk of a leak due to my fiddling/pushing on the tubes.

However, if worst comes to worst i'll just have to install the card with the tray already in the case. I'll see how i go.

Thanks for ruining my evening!

Lol, J/K