I had no problems with the e8600 and 4/5 with this p5e, the gskill & bios 0903. With 420fsb and 4/5 the ram will be at 1050mhz, but if your ram is good up to 1140mhz you can go up to 456fsb with any multiplier to match max ram speed with 4/5 divider and 266strap. In any case you can also try with 1:1 or 5/6 with 333strap or 1:1 and 3/4 divider with 400strap. The problem of no post could be also the bios settings of dram static read control, ai clock twister or transaction booster, how do you have them configured?