I doubt it, I got the P182 and while its the best case I have used so far its not really designed for Crossfire/SLI set-ups. The lowest card is too near the floor of the case and thats using a single slot cooler!

I guess it may depend a bit on motherboard layout as some may have the PCI-Slots raised a bit higher on the PCB?

But 99.9% sure you won't be able to use a second card with the Accelero S1 on, its flippen MAHOOOSIVE!