You will need a bios setting of 1.6v or higher to attain 4500 MHz. You will also need a very good cooling system, water preferably, or a very good heatsink/fan. Stock heatsink/fan is insufficient.

To get there, increase your voltage by 0.250v each time you have upped the CPU clock. If it is too low, it will:
1) Not load to the windows screen, add more
2) Not fully load to windows, add more
3) Load to windows, but bsod very quickly
4) load to windows, bsod when running a program
5) Load to windows, runs program, reduce volts in smallest increments until stability is decreased.

You will also have to control PLL and VTT settings if available on your MB.
Start with a PLL of 1.60v, and increase it very little.
Start with a VTT of 1.20v, and increase it slowly.