Which bios, i assume you meant 266/666 4:5 not 333/600 ??? 4:5 operates on 266 fsb strap which is tighter than 2:3 and 5:6. Prior to 12/28 beta bios 4:5 and 5:8 and 3:5 was very unstable but 12/28 beta bios fixed 4:5 and 5:8 divider so that 4:5 is working up to ~440FSB http://i4memory.com/showthread.php?p=82600#post82600
I am now using 1/11 official bios and managed with my E8500 on 4:5 (266/666) divider to around 480FSB for 600mhz 5-5-5-x which needed more vdimm than on say 2:3 or 5:6 divider ~0.05-0.10v more vdimm.
If you're using 4x1GB and 4:5 divider then I can imagine how much stress is on NB with how tightly set that strap is.
DFI said 4:5 and 3:5 divider stability issues aren't just on DFI X38 but exist on other brand X38 chipset boards too apparently i.e. Asus X38. I know Gigabyte X38-DQ6 had similar issue with several dividers messed up.
Strange my Asus P35 chipset boards didn't have such issue on 4:5.
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