doesnt really matter .. even 1.45v during full load = 1.5+v set in bios can degrade ur CPU over months ... say 3 to 6 months ...
many people have report that their CPU was stable orthos 24hrs when they bought it , but 4,5 months later it isnt.... after 1.45+v 24/7 ...
it depends on ur cooling as well .. keep the temp below 50C or near 50C helps it degrade slower .. i guess
to get E6600 3.6GHz orthos stable ... it needs at least around 1.45v during full load with decent aircooling (or 1.5+v set in bios for most boards) for MOST of the E6600's (check oveclocking database) (yes there r chips can do that for <1.4v but rare)
and yes water do allow a bit higher vcore compare to air such that the 2 degrades the same in the same period
so i dunno ... if u upgrade often say 3 months cycle .. go for 1.6v as it prolly wont matter after 3 months .. might degrade a bit
i had an E6400 (i have E6600 now) i used to run it 3.4GHz @ 1.59v set in bios ... 1.56v idle , 1.54v full load ... it degrade a bit .. the same 1.59v set in bios wont get it over 415fsb or 3.32GHz .. right now its stable @ 3.28GHz 410fsb. it degrade about 120Mhz over about 6 months @ 1.59v set in bios. lol 15fsb, but that CPU had 425fsb wall anyway..
Edit: i had E6400 + DS3 + Bigtyphoon with 120CFM fan ... about the same as tower 120 .. temps were 65C load i think
thats jsut my experience ... i did changed bios and stuff though ... for a couple months i did ran it on 975XBX with 1.59v set in bios , too. then i changed back to DS3
chances r if u set 1.6v in bios ur getting 1.57v idle , 1.55v load .... and from my experience.. it WILL degrade ,
but ummm ... well as long as u keep ur temps below 70C @ load i think ur good ... i think its safe to say that any vcore above default WILL degrade ur CPU, the difference is how long.
EDIT:
as for CPU jsut completely dead like Northwood .. i really dont think its gonna hapnend to anyone, again it will degrade.. but not dead


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