I think it's better to leave Loadline Calibration disabled. If I would want it to run stable with Loadline Calibration enabled it's going to need more voltage across the board to keep it stable and question is if it would still be possible to use the same clock skews. It's what I think the reason why it's so difficult to keep it stable running.

My conclusion is that Loadline Calibration disabled improves stability. Enabling Loadline Calibration results in kernel panics and it never did that with Loadline calibration Disabled at 100% load. Maybe when I've got the time to do it I'll try to find stability with Loadline Calibration to actually see the differences between enabled and disabled.