That's a loaded question. If you want absolute safety, I'd suggest running at stock settings.
Intel does provide a recommended and absolute max voltage settings they spell out in their data sheets. The absolute max voltages they supply with a disclaimer that states it might harm your processor to run at those settings. So, it's up to each person to determine how much risk they are comfortable with.
Here is a link to the data sheets:
http://www.intel.com/design/corei7/documentation.htm
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