4 or 8GB is going to need skew delay...you can force the modules and NB to work with juice but both will die over time. Also 4GB and 8GB using 1600EB is having a spec change due to board issues, 7-6-6- is moving to 7-7-6 as its far easier on the board and chipset.
8GB also adds a ton of load to the NB, voltages over 1.4 create to much heat, 1.35 to 1.375 V is all I have needed for 8GB at 7-7-6-24 250ps delay on A and B DDr3 1600 with 9650 at 3.6 and now testing 4GHZ. PF7 rest of timings AUTO, NB GTL 61%
The more load you add the more Jitter the board sees, the harder it is to clock the ram. X48, X38, P35, P45 all need skew with 4 and 8GB, NB GTL tuning also with FSB below 1600, over 1600 add CPU GTL also if you have a quad.
The days of easy overclocking are gone if you have either 8GB, a quad or both.
This with a P5E3 Premium, 8GB of 1333 Reaper 6-6-6-24 dimms @ 7-7-6-24 DDR3 1600
In bios you may have 2 options for skew, just A and B try setting 200 to 250ps delay for both
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