Mushkin Redline XP4000 is some of the fastest memory that you can buy, but it requires special handling that will not be everyone’s cup of tea. You need to feed it about 3.5V for best performance. Only one production board family supplies those voltages out of the box – the DFI nForce4 series Ultra or SLI. If you want to use another board, you may be able to use the OCZ DDR Booster, which costs about $40, to supply the higher voltages. The DDR Booster won’t work on every motherboard, but it does work on most. Or lastly, you could go on Enthusiast Forums to find the latest volt mod for your favorite motherboard. Just keep in mind that a volt mod will almost surely void your warranty.
http://www.anandtech.com/memory/showdoc.aspx?i=2416