Yes to 4 x 2.5 inch drives
Yes to USB 3 on the Front +Headphone/Mic jacks(set to one side so not to get in the way of the MoBo)
Yes to Slim DVD Drive Bay
Yes to ITX/mATX fitting
Yes to fitting a 2 slot graphics card
Yes for room to fit a third party HSF
Yes to better cable management

But remember you are building for a "Niche Market" here and some people would like room to fit a H100 in there for a bit of OCing.


Maybe someone in your office could try building a PC with a ASUS Maximus V Gene, i3770, 2x8GB Corsair Dominator, Zotac GTX650 and 1xSSD + 2x2.5 1TB drives. Just do a search in this site of the most popular components used, the ones I have are just off the top of my head for an example.