I've been having an issue with my USB mouse that I believe may be related to the computer going into sleep mode.

The computer comes out of sleep mode fine, except that the mouse sometimes will not respond unless I unplug it from the USB and then plug it back in. After that, sometimes there is unusual behavior with the mouse and clicking, for example, sometimes I can't seem to click the "back" button on my browser even though other things still click.

I believe it started when I plugged in a second monitor as an extended desktop. I tried switching from my Nvidia 480 to an ATI card, but it didn't help resolve the issue.

I'm going to try some more testing by going back to one monitor and or disabling sleep mode to see if the problems happen. I've tried various USB 2.0 and 3.0 ports front and back, but it doesn't seem to make a difference.

Any other ideas?