Is you E8500 a C0 or E0? If it's the latter it should do 4.3 - 4.4GHz on safe-ish vcore. Your 1800 MHz ram should do 1800 MHz, but without knowing model/IC's I cant advise some timings to try. Back it off to 9-9-9-X and see if that helps.
Skews are a trial and error thing, there's articles that tell you the principle of their operation, but as to what settings may help you, that only you can work out for your gear.
You most certainly can use 'low voltage' (by this I assume you mean 1.65v X58 kits) on the board - I'm using 2 x 2GB G.Skill Elpida BBSE kit at 1.62 vdimm for DDR3-1780MHz 7-8-7-20 1T. There's many P55 kits that should work too.
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