When I made the switch to 64bit Vista I only found one of my 32 bit programs that wouldn't work with Vista. It was Studio 10, I went to the web site for the software and they had a free download of the program for use with 64 bit operating systems. Some software comes in both 32 bit and 64 bit versions because 64 bit software is incompatible with a 32 bit operating system. You can run 32 bit software on a 64 bit operating system but you can't do it the other way around. You will see more 64 bit software as 64 bit operating system use grows. Some point down the line you will see the end of 32 bit all together, but its still years off.