Well the CPU (and GPU) will be under water so no additional
airflow will be coming from the CPU fan, however, I do have
a 250mm fan on the case side (Sharkoon Seraphim case).

I doubt I will overclock the CPU by much (if at all) so 4+1
should be fine?

What is the verdict on Asus M3A78-T pwm design? Ok or not.
Or should I wait for the M4A78-E which has 8+1 design?