Quote Originally Posted by corex2 View Post
The system wont boot with my gtx280 in the first slot, fans start to blow then slow down then blow again then slow down, but no post to the bios ??? any ideas why
Just a guess: sounds to me like one of the 12V rails on your power supply is overloaded and shutting down. You may need a bigger/better supply for this graphics card.

Really wild guess: did you attach the auxiliary 6-pin power cable to the video card? This card draws more than 75W which is the maximum the PCI-e connector will supply.