I recently replaced my 6600 with an 8500 CPU on my 1.02g P5WDH (summer 2006 vintage).
It went fairly smoothly. I had to run BIOS 1801 to get rid of a microcode update error, and it took a few installs and a CMOS clear to make that work, and also to get back the 9.5 multiplier.
The CPU voltage has to be left on auto (CPU-Z reads 1.18V) as the lowest manual voltage in the menu is above the rated 1.26V maximum for this CPU. I also left C1E enabled since the voltage is auto.
The limitation to overclocking with my board is the north bridge (MCH). First, HyperPath3 must be disabled. Second, it needs a good heat sink (I use a tower HR-05). Third, it maxes out at 375 with 4-4-4-12-4 timing and 385 with SPD timing (375 at 1.60V, 385 at 1.65V).
I settled on the 375 timing (CPU at 3.567 GHz), which runs the NB a bit cooler and gives slightly better system performance due to better memory timings.
I have an original Ninja on the CPU with a slow Nexus fan. At idle, the fan is set at 44% (630 RPM - silent) and the CPU is 48C. Under Orthos, the fan speeds up to 65% and the CPU is 63C (the SpeedFan set point). The room ambient was 25C when these temperatures were measured.
Although this wonderful motherboard is very near end of life, it ain't quite dead yet!

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