well:
had a huge vdrop ~ 0,5-0,8v
serious problems with various ram sticks
problems with 65nm cpus
no waterblocks at that time.

was the first board besides asus for years...well I've rly seen so many problems with the s2e, don't know maybe I'm just a lucky one with the ones I bought.
atm I'm testing a set of 4x2gb 1333 and 4x2gb 1600 corsairs, seems to work so far.