At least they're making educated guesses. You're just applying the 'trust the company! You don't know anything!' principle.
I've worked in a clean room before, with 3 inch silicon wafers making microchannels. Even with only two designs per channel, sometimes things just go wrong. Of course, my developer is much, much thicker and after I do UV exposure the I just wash off the undeveloped stuff, but if I can get errors even at that stage of the process you can imagine how things will go wrong when you're etching many, many more layers at the nanometer scale.
Trust your company all you want; but the thing is if one, just one thing, goes wrong, the whole die is already gone. Especially for a GPU. If nvidia had a couple SP's destroyed, it's no longer a GTX 280. Even worse if the errors are in other, less fault tolerant parts. This ain't like a CPU, where you can disable things with a laser and sell it at a lower price. Nvidia either has a GTX 260 or a 280, and the 280 requires this huge die to be perfect in every way. And it really isn't, considering the low clocks and it's failure to reach a 1 TFLOP output.
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