I've never owned the Rampage but I did have the Maximus Formula which I then converted to the Rampage Formula. The only reason I can see sticking with the x38/x48 chipsets is if you need dual x16 lanes for crossfire or if you wanted to run a RAID controller in one 16x lane and still wanted to keep the other 16x lane for graphics. Honestly I can't see x8/x8 being much of a bottle neck unless you live to run 3D benchmarks all the time. When the 4870 comes out I'll more than likely CF them on this board unless, of course, the 4870x2 proves to be a superior card.
My experience has been that the P45 clocks the FSB higher for quadcores with much less effort and heat than the x38/x48 chipset. I could never run 450MHz on my QX6850 using my old Maximus board and 4x1GB of memory. The highest I ever acheived was 425-430MHz and that was with 1.60V+ on the north bridge but here I am doing 450MHz with 4x1GB @ 1125MHz with only 1.28V on the NB.







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