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I have been happy to find that it is possible to run the XMP profile #1 with
4 x 1gb of Crucial Ballistix PC3-12800. With a FSB of 425 this puts the
memory at 1700mhz.

I have recently switched processors from a Q6600 to a E8500. The E8500
needs 1.35 volts to operate at 4ghz. While massaging the various parameters
in a effort to lower the core voltage, I decided to try a lower multiplier.
(500 x 8). I made the adjustment in the bios, leaving the memory on profile #1. The Bone presented me with a nice blue screen with instructions to run "disk clean" AND to reauthorize Vista! I had to do this, why I don't know
except some corruption must have happened to the ms files.
Later on I gave it another try, but this time I lowered the memory to a 1:1
ratio before changing the cpu. When it booted up it stopped before windows
with a notice that a file was missing or corrupted and that I needed to run
Vista startup repair. I did this and was able to boot into Vista this time.
Operation was as expected and passed all stability tests. However, it wasn't any better than the previous 425 x 9.5 setting.

As others have noted, this motherboard does not like changes! Almost any memory change will result in a "no boot" condition. Incidently, it has not been possible to make any changes at all in the gtl settings. One click off the automatic number = "no boot".

After the Bone has been adjusted to the settings that "it" likes, it is perfectly stable in all respects. However, it should not be such a hassle to get to this stage. This bios is by far the worst I have ever encounted, you would expect better from Intel!